主要研究方向： 1）消化道的感觉、运动和免疫功能及其调控。 2）肠隐窝干细胞增殖分化及其在肠炎发生中的作用； 3）生理、病理条件下胃肠道感觉、运动及肠粘膜屏障的改变及调节机制。 4）神经系统应激以及抑郁症等精神疾病发生的神经机制及其抗抑郁药物作用的细胞与分子机制 5）从事神经发育和中枢神经损伤及保护作用的研究
主持的课题： 1. 缩宫素对肠道黏膜固有层巨噬细胞极化的调节及其在IBD发生中的作用，2019-2022，直接经费60万元（刘传勇） 2. 小胶质细胞源性IL-1β通过SSH1/Cofilin调控突触可塑性介导抑郁症发病的机制研究（2019.1-2022.12: 国家自然基金（面上基金）基金号：81873796，于书彦） 3. 国家自然科学基金（面上项目）：81873768，H2S调控BMSCs外泌体相关miR-9/TN-C轴对HIBD后的神经保护作用及机制研究，2019.01-2022.12，56万，在研，王贞主持。 4. 国家自然基金面上项目“雌激素膜受体GPER激活诱导潘氏细胞成熟在维持肠干细胞微环境中的作用及机制研究”（31771278），2018/01-2021/12，薛冰 5. 胚胎源性H2S在母-胎免疫耐受诱导中的作用及其机制（2018.01-2021.12 NSFC NO：81771601, 55 万，李景新） 6. 人肠神经元PAR-1介导的信号传导通路在IBD发生发展中的作用（国家自然科学基金，面上项目，2018. 01-2021. 12, NO: 81770542, 李勤主持） 7. TRPV1通道在诱发肠道炎症反射中的作用及其机制研究，2017–2020年，直接经费65万元，刘传勇 8. 国家自然科学基金（面上项目）：81671213，利用条件基因敲除技术研究内源性H2S调控Shh通路对HIBD后新生小鼠海马神经再生的影响，2017.01-2020.12，57万，在研，王贞主持。 9. 肠道内源性缩宫素信号系统对肥大细胞脱颗粒的影响及其在内脏高敏感性发生中的作用，经费88万元，刘传勇 10. 缩宫素诱导肠免疫耐受及其相关机制国家自然基金面上项目（2016.01-2019.12 NSFC NO：31571183, 76 万，李景新） 11. miRNA-134介导的突触可塑性调节在抑郁症发病中的作用及机制研究（2015.1-2018.12: 国家自然基金（面上基金）基金号：81471371，于书彦） 12. 国家自然基金面上项目，81470910，BDNF对脊髓二级感觉投射神经元GABAA受体的调节机制及其在内脏痛中的作用，2015/01-2018/12， 67万，项目负责人：马雪莲 13. 肠上皮γ-氨基丁酸能系统介导肠粘膜免疫及其机制。国家自然基金面上项目（2012.01-2015.12 NSFC NO：31171108 62万，李景新） 14. 谷氨酸受体介导的突触可塑性在抑郁症发病中的作用与机制。（2012.1-2014.12: 国家自然基金（青年基金）基金号：81101006，于书彦） 15. 国家自然科学基金青年项目“AH神经元在缩宫素调节内脏敏感性中的作用及其机制”（31100837），2012/01-2014/12，薛冰 16. 山东省重点研发计划项目：2017GSF218091，左旋半胱氨酸调控Sonic Hedgehog通路对SAH大鼠及患者后认知功能障碍的影响及临床应用初探，2018.01-2019.12，10万，在研，王贞主持。 17. IL-1β介导的神经可塑性调节在抑郁症发病与治疗中的机制研究（2018.1 – 2019.12: 山东省重点研发计划基金号：2018GSF118050，于书彦） 18. 类脑计算关键技术及其多模态信息处理应用 (2017.1-2019.12: 山东省重大科技创新工程项目（子课题）基金号：2017CXGC1504 ，于书彦) 19. 山东省重点研发计划“潘氏细胞雌激素膜受体GPER激活对化疗性胃肠综合征的保护作用及其机制”（2017GSF218011），2017/01-2018/12，薛冰 20. 山东省自然科学基金面上项目“肠神经系统G蛋白偶联雌激素受体GPER表达调控及其参与慢性传输型便秘的机制”（ZR2016HM51），2016/11-2019/12，薛冰 21. 应用微丝电极阵列模块研究抑郁症的发病机制及其药物治疗(2015.1 – 2016.12: 山东省重点研发计划基金号：2015GGH318024，于书彦 ) 22. SIRT1调控抑郁症大鼠杏仁核突触可塑性的研究（2014.10-2016.10：中国博士后科学基金特别资助基金号：2014T70650，于书彦） 23. 2014年人社部56批博士后面上一等资助（8万），主持，王蓉
发表的文章： 1. Ma X, Sun Q, Sun X, Chen D, Wei C, Yu X, Liu C, Li Y, Li J.Activation of GABAA Receptors in Colon Epithelium Exacerbates Acute Colitis. Front Immunol. 2018 May 7;9:987. 2. Fan C, Song Q, Wang P, Li Y, Yang M, Liu B, Yu SY*. Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1β Pathway in Rats. Neuroscience. 2018, 392: 92-106. PubMed 3. Fan C, Zhu X, Song Q, Wang P, Liu Z, Yu SY*. MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats. Neuropharmacology. 2018, 131: 364–376. PubMed 4. Xin D#, Chu X, Bai X, Ma W, Yuan H, Qiu J, Liu C, Li T, Zhou X, Chen W, Liu D, Wang Z*（王贞）. l-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation. Brain Behav Immun. 2018 Oct;73:222-234. PubMed 5. Ji H, Liu N, Yin Y, Wang X, Chen X, Li J, Li J.Oxytocin inhibits ovarian cancer metastasis by repressing the expression of MMP-2 and VEGF.J Cancer. 2018 Apr 6;9(8):1379-1384. 6. Wang R, Han MT, Lv XL, Yu YA, Chai SQ, Qu CM, *Liu CY. Inhibitory action of oxytocin on spontaneous contraction of rat distal colon by nitrergic mechanism: involvement of cyclic GMP and apamin-sensitive K+ channels. Acta Physiol (Oxf). 2017 Apr 26. doi: 10.1111/apha.12890. [Epub ahead of print] PubMed 7. Ting Han, Yan Tang, Jing Li, Bing Xue, Liping Gong, Jingxin Li, Xiao Yu, and * Chuanyong Liu. Nitric oxide donor protects against acetic acid-induced gastric ulcer in rats via S-nitrosylation of TRPV1 on vagus nerve. Sci Rep. 2017; 7: 2063. doi: 10.1038/s41598-017-02275-1. PubMed 8. Liu S#, Xin D, Wang L, Zhang T, BaiLi T, Xie Y, Xue H, Bo S, Liu D, Wang Z*（王贞）. Therapeutic effects of L-Cysteine in newborn mice subjected to hypoxia-ischemia brain injury via the CBS/H2S system: role of oxidative stress and endoplasmic reticulum stress. Redox Biology 2017 Jul 14; 13:528-540. PubMed 9. Li T#, Wang L#, Hu Q, Liu S, Bai X, Xie Y, Zhang T, Bo S, Gao X, Wu S, Li G*, Wang Z*（王贞）. Neuroprotective Roles of l-Cysteine in Attenuating Early Brain Injury and Improving Synaptic Density via the CBS/H2S Pathway Following Subarachnoid Hemorrhage in Rats. Frontiers in Neurology. 2017 May 2; 8:176. doi: 10.3389/fneur.2017.00176. eCollection 2017. PubMed 10. Ge L#, Wei LH, Du CQ, Song GH, Xue YZ, Shi HS, Yang M, Yin XX, Li RT, Wang XE, Wang Z*（王贞）. Song WG*. Hydrogen-rich saline attenuates spinal cord hemisection-induced testicular injury in rats. Oncotarget. 2017 Jun 27; 8(26):42314-42331 PubMed 11. Hu Q#, Li T#, Wang L, Xie Y, Liu S, Bai X, Zhang T, Bo S, Xin D, Xue H, Li G*, Wang Z*（王贞）. Neuroprotective Effects of a Smoothened Receptor Agonist against Early Brain Injury after Experimental Subarachnoid Hemorrhage in Rats. Frontiers in Cellular Neuroscience. 2017 Jan 18;10:306 PubMed 12. Li T#, Liu H, Xue H, Zhang J, Han X, Yan S, Bo S, Liu S, Yuan L, Deng L, Li G*, Wang Z*（王贞）. Neuroprotective effects of hydrogen sulfide against early brain injury and secondary cognitive deficits following subarachnoid hemorrhage.Brain Pathology. 2017 Jan;27(1):51-63. PubMed 13. Gong L, Li J, Tang Y, Hang T, Wei CF, Yu X, Li JX, Wang R, Ma XL, Liu KJ, Geng LY, Liu SZ, Yan B, *Liu CY. The antinociception of oxytocin on colonic hypersensitivity in rats was mediated by inhibition of mast cell degranulation via Ca2+-NOS pathway. Sci. Rep. 6, 31452; doi: 10.1038/srep31452 (2016). PubMed 14. Wang R, Guo LY, Suo MY, Sun Y, Wu JY, Zhang XY, * Liu CY. Role of the nitrergic pathway in motor effects of oxytocin in rat proximal colon. Neurogastroenterol Motil. 2016 2016 Dec;28(12):1815-1823. PubMed 15. Xu T, Yang Q, Liu R, Wang W, Wang S, Liu C, Li J. Ethanol impedes embryo transport and impairs oviduct epithelium.Toxicology. 2016 May 16;357-358:44-51. doi: 10.1016/j.tox.2016.06.001. （通讯作者） 16. Ailin Xiao, Jing Li, Tianjian Liu, Zhuxi Liu, Chuanfei Wei, Xiaomeng Xu, Qin Li* and Jingxin Li*. L-Cysteine enhances nutrient absorption via a cystathionine-β-synthase-derived H2 S pathway in rodent jejunum. Clin Exp Pharmacol Physiol. 2016 May; 43(5): 562-568 17. Zhu X, Gao R, Liu Z, Cheng Z, Qi Y, Fan C, Yu SY *. Ginsenoside Rg1 reverses stress-induced depression-like behaviors and BDNF expression within the prefrontal cortex. European Journal of Neuroscience. 2016, 44: 1878-1885. PubMed 18. Liu Z, Qi Y, Cheng Z, Zhu X, Fan C, Yu SY *. The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats. Neuroscience. 2016, 322: 358–369. PubMed 19. Zhang Q#, Liu S, Li T, Yuan L, Liu H, Wang X, Wang F, Wang S, Hao A, Liu D*, Wang Z*（王贞）. Preconditioning of bone marrow mesenchymal stem cells with hydrogen sulfide improves their therapeutic potential.Oncotarget. 2016 Sep 6;7(36):58089-58104. PubMed 20. Bai X#, Liu S, Yuan L, Xie Y, Li T, Wang L, Wang X, Zhang T, Qin S, Song G, Ge L*, Wang Z*（王贞）.Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice.Brain Research. 2016 Sep 1;1646:410-7.PubMed 21. Yuan L#, Liu S, Bai X, Gao Y, Liu G, Wang X, Liu D, Li T, Hao A,Wang Z*（王贞）.Oxytocin inhibits lipopolysaccharide-induced inflammation in microglial cells and attenuates microglial activation in lipopolysaccharide-treated mice.Journal of Neuroinflammation. 2016 Apr 13;13(1):77. PubMed 22. Li Y，Xu J，Jiang F，Jiang Z，Liu C，Li L，Luo Y，Lu R，Mu Y，Liu Y， *Xue B(通讯作者).G protein-coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57BL/6 female mice. Neurogastroenterol Motil，2016.3.01，28（3）：432~442 23. Li Q*, Michel K*, Annahazi A, Demir IE, Ceyhan GO, Zeller F, Komorowski L, Stöcker W, Beyak MJ, Grundy D, Farrugia G, De Giorgio R, Schemann M. Anti-Hu antibodies activate enteric and sensory neurons. Sci Rep. 2016 Dec 1; 6: 38216 24. Modulation of intestinal afferent nerve sensitivity to inflammatory mediators following systemic endotoxin in mice., Xue B, Kasparek MS, Müller MH, Kreis ME. Neurogastroenterol Motil. 2015 ;27(4):550-8 25. Oxytocin down-regulates mesenteric afferent sensitivity via the enteric OTR/nNOS/NO/KATP pathway in rat. Li J, Xue B, Han T, Huang K, Gong L, Ma X, Liu K, Cui S, Zhang M, Kunze W, Liu C. Neurogastroenterol Motil. 2015 ;27(1):51-62 26. Gong L, Gao F, Li J, Li J, Yu X, Ma X, Zheng W, Cui S, Liu K, Zhang M, Kunze W, *Liu CY. Oxytocin-induced membrane hyperpolarization in pain-sensitive dorsal root ganglia neurons mediated by Ca(2+)/nNOS/NO/KATP pathway. Neuroscience. 2015 Mar 19;289:417-28. PubMed 27. Li J, Xue B, Han T, Huang K, Gong L, Ma X, Liu K, Cui S, Zhang M, Kunze W, *Liu C. Oxytocin down-regulates mesenteric afferent sensitivity via the enteric OTR/nNOS/NO/KATP pathway in rat. Neurogastroenterol Motil. 2015 Jan;27(1):51-62. PubMed 28. Xiao A, Wang H, Lu X, Zhu J, Huang D, Xu T, Guo J, Liu C, Li J. H2S, a novel gasotransmitter, involves in gastric accommodation. Sci Rep. 2015 Nov 4;5:16086（通讯作者）(IF: 5.597 5-year impact factor) 29. Chen D, Zhao J, Wang H, An N, Zhou Y, Fan J, Luo J, Su W, Liu C, Li J. Oxytocin evokes a pulsatile PGE2 release from ileum mucosa and is required for repair of intestinal epithelium after injury. Sci Rep. 2015 Jul 10;5:11731. doi: 10.1038/srep11731（通讯作者）(IF: 5.597 5-year impact factor) 30. Zhang Q#, Yuan L#, Zhang Q, Gao Y, Liu G, Xiu M, Wei X, Wang Z* （王贞）, Liu D*. Resveratrol attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. International Immunopharmacology. 2015 Jul 27;28(1):578-587. PubMed 31. Lu W, Li J, Gong L, Xu X, Han T, Ye Y, Che T, Luo Y, Li J, Zhan R, Yao W, Liu K, Cui S, *Liu C. Hydrogen Sulfide Modulates Duodenal Motility in Male Rats via Activating TRPV1 and KATP channels. Br J Pharmacol. 2014 Mar;171(6):1534-50PubMed abstract 32. Zhao D, Ning N, Lei Z, Sun H, Wei C, Chen D, Li J. Identification of a Novel Protein Complex Containing ASIC1a and GABAA Receptors and Their Interregulation. PLoS One. 2014 Jun 12;9(6):e99735.（IF: 4. 244 5-year impact factor） 33. Zhang D, Li X, Yao Z, Wei C, Ning N, Li J. GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation. Cancer Lett. 2014 Jun 28;348(1-2):100-8. 34. Nannan Ning, Jianchun Zhu, Yahui Du, Xiaolin Gao, Chuanyong Liu, Jingxin Li.Dysregulation of hydrogen sulfide metabolism impairs oviductal transport of embryos. Nat Commun. 2014 Jun 10;5:4107.（通讯作者）（IF: 10. 02 5-year impact factor） 35. Zhang Q#, Yuan L, Liu D, Wang J, Wang S, Zhang Q, Gong Y, Liu H, Hao A, Wang Z* （王贞）.Hydrogen sulfide attenuates hypoxia-induced neurotoxicity through inhibiting microglial activation. Pharmacological Research. 2014 Jun;84:32-44. PubMed 36. Liu D#, Xie K, Yang X, Gu J, Ge L, Wang X, Wang Z*（王贞）. Resveratrol reverses the effects of chronic unpredictable mild stress on behavior, serum corticosterone levels and BDNF expression in rats. Behavioural Brain Research. 2014 May 1;264:9-16.PubMed 37. Liu D#, Zhang Q, Gu J, Wang X, Xie K, Xian X, Wang J, Jiang H, Wang Z*（王贞）. Resveratrol prevents impaired cognition induced by chronic unpredictable mild stress in rats. Prog Neuropsychopharmacol Biol Psychiatry. 2014 Mar 3;49:21-9. PubMed 38. Wang Z#（王贞）, Zhang Q, Yuan L, Wang S, Liu L, Yang X, Li G*, Liu D*. The effects of curcumin on depressive-like behavior in mice after lipopolysaccharide administration. Behavioural Brain Research. 2014 Nov 1;274:282-90. PubMed 39. Wang Z#（王贞）, Liu D, Zhang Q, Wang J, Zhan J, Xian X, Du Z, Wang X, Hao A*.Palmitic acid affects proliferation and differentiation of neural stem cells in vitro. Journal of Neuroscience Research, 2014 May;92(5):574-86.PubMed 40. Zhang L, Luo JX, Zhang M, Yao W, Ma X, Yu SY *. Effects of curcumin on chronic unpredictable mild stress-induced depressive-like behavior and structural plasticity in the lateral amygdala of rats. The International Journal of Neuropsychopharmacology. 2014 ; 17（05）:793-806 PubMed 41. Buhner S*, Braak B*, Li Q*, Kugler E M*, Klooker T, Wouters M, Donovan J, Vignali S, Mazzuoli-Weber G, Grundy D, Boeckxstaens G, Schemann M. Nerve activation by mucosal biopsy supernatants from irritable bowel syndrome patients is linked to visceral sensitivity. Exp Physiol 2014 Oct; 99(10):1299-1311（* Authors equally contributed to this work） 42.Xuelian Ma*(马雪莲), Weiying Bao, Xiujun Wang, Zhilong Wang, Qiaoran Liu, Zhenyu Yao, Di Zhang, Hong Jiang, Shuang Cui, Role of spinal GABAA receptor reduction induced by stress. Experimental Brain Research. 2014, 232（11）:3413–3420. |
