薛冰
从事生理及病理条件下胃肠道感觉、运动及肠粘膜屏障的改变及调节机制,关注雌激素在肠道运动、感觉及肠粘膜屏障维护中的作用。利用肠系膜传入神经放电、膜片钳等电生理技术结合传统免疫组织化学、分子生物学、细胞培养等方法,以肠神经丛、肠隐窝干细胞、潘氏细胞为靶点研究胃肠道感觉、运动调节及肠粘膜修复机制。
1、大学开始受教育经历
2004.09-2008.12,山东大学医学院病理生理教研室,研究生/博士
1998.09-2001.07,山东大学医学院生理学教研室,研究生/硕士
1991.09-1996.07, 原山东医科大学临床医学系,本科/学士
2、研究工作经历
2008.09-至今,山东大学医学院病理学与病理生理学系,副教授
2006.07-2008.08,德国慕尼黑大学Walter Brendel Institute for Surgical Research,访问学者
2001.09-2008.09,山东大学医学院病理生理教研室,讲师
1996.07-1998.09,原山东医科大学生理学教研室,助教
3、发表期刊论文
①Li Y,Xu J,Jiang F,Jiang Z,Liu C,Li L,Luo Y,Lu R,Mu Y,Liu Y, Xue B(通讯作者),G protein-coupled estrogen receptor is involved in modulating colonic motor function via nitric oxide release in C57BL/6 female mice.,NeurogastroenterolMotil,2016.3.01,28(3):432~442
②Xue B, Kasparek MS, Müller MH, Kreis ME. Modulation of intestinal afferent nerve sensitivity to inflammatory mediators following systemic endotoxin in mice.NeurogastroenterolMotil. 2015 ;27(4):550-8
③Li J, Xue B, Han T, Huang K, Gong L, Ma X, Liu K, Cui S, Zhang M, Kunze W, Liu C. Oxytocin down-regulates mesenteric afferent sensitivity via the enteric OTR/nNOS/NO/KATP pathway in rat. NeurogastroenterolMotil. 2015 ;27(1):51-62
④Xue B, Müller MH, Li J, Pesch T, Kasparek MS, Sibaev A, Hausmann M, Rogler G, *KreisME.Mast cells and the cyclooxygenase pathway mediate colonic afferent nerve sensitization in a murine colitis model Auton Neurosci.174(1-2):47-53,2013.
⑤Che t, Sun H, Li J, Yu X, Zhu DX, Xue B, Liu K, Zhang M, Kunze W, *Liu C. Oxytocin hyperpolarizes cultured duodenum myenteric intrinsic primary afferent neurons by opening BKCa channels through IP3 pathway, J Neurochem. 121(4):516-25,2012
⑥Xue B, Hausmann M, Müller MH, Pesch T, Karpitschka M, Kasparek MS, Hu WC, Sibaev A, Rogler G, *Kreis ME. Afferent nerve sensitivity is decreased by an iNOS-dependent mechanism during indomethacin-induced inflammation in the murine jejunum in vitro. NeurogastroenterolMotil. 21(3):322-34,2009
⑦Mueller MH, Xue B, Glatzle J, Hahn J, Grundy D, *Kreis ME. Extrinsic Afferent Nerve Sensitivity and Enteric Neurotransmission in Murine Jejunum in vitro. Am J PhysiolGastrointest Liver Physiol. 297(4):G655-62 ,2009
⑧Mueller MH, Karpitschka M, Xue B, Kasparek MS, Sibaev A, Glatzle J, *Kreis ME. Intestinal afferent nerve sensitivity is increased during the initial development of postoperative ileus in mice.JGastrointest Surg. 13(3):423-31,2009
⑨Xue B, Li JX, Liu Zh-X,ChaiQ,Chen L-B.Effect of total flavonoid fraction of AstragaluscomplanatusR.Brown on angiotensin II-induced portal-vein contraction in hypertensive rats.Phytomedicine .2008;15 :759–762
⑩Li Jx, Xue B, Chai Q, Liu Zx, Zhao Ap, Chen Lb Antihypertensive effect of total flavonoid fraction of Astragaluscomplanatus in hypertensive rats..Chin J Physiol. Chin J Physiol. 2005, 30;48(2):101-6
4. 主持及主要参与基金项目:
1. 国家自然科学基金青年项目(31100837):AH神经元在缩宫素调节内脏敏感性中的作用及其机制(2012/01-2014/12)
2. 2.山东省自然科学基金面上项目(ZR2016HM51),肠神经系统G蛋白偶联雌激素受体GPER表达调控及其参与慢性传输型便秘的机制,2016/11-2019/12
3.第51批中国博士后面上基金:雌二醇非基因组效应在内脏感觉调节中的作用
4.国家自然基金重点项目(81330012):在体示踪益生菌治疗肠易激综合征的微生态动力学研究、2014年/01-2018/12(第二位)
5.教育部博士点基金(9131110046):肌间神经丛内硫化氢抑制胃运动的生理意义及其机制研究(2010/01-2012/12)(第二位)