山东大学 | 基础医学院 | 原生理学教研室 | 原病理生理学教研室

 

师资力量 当前位置: 首页 > 师资力量 > 正文  
于书彦
作者:  来源:  发布时间:2018年11月26日 18:52  浏览次数:

于书彦

教授,博士研究生导师。山东生理学会秘书长、常务理事,加拿大英属不列颠哥伦比亚大学(UBC)访问学者。

于书彦教授长期从事抑郁症等神经、精神类疾病的研究。主要运用病毒学、遗传学、药理学、电生理及行为学等技术手段,从不同层次研究抑郁症的神经生物学发病机制及实验性治疗新策略。以通讯作者在国际学术期刊The Journal of Clinical InvestigationBrain Behavior and ImmunityJournal of NeuroinflammationInternational Journal of Neuropsychopharmacology等杂志发表SCI论文20余篇;先后主持国家自然科学基金4项、省部级科研项目、山东省重大专项等20余项。获得山东省教学成果二等奖、山东省生理学教学设计比赛一等奖、山东大学教学成果一等奖等。

联系地址:济南市文化西路44号山东大学医学院生理学系 250012
电话:0531-88382571
E-mail
shuyanyu@sdu.edu.cn


学习与工作经历

1999-2002 山东大学医学院生理学系 硕士

2005-2008 山东大学医学院生理学系 博士

2006-2007 加拿大不列颠哥伦比亚大学脑研究所  公派访问学者

2002-2016 山东大学医学院生理学系 讲师/副教授,硕士研究生导师

2016-至今 山东大学医学院生理学系 教授,博士研究生导师


主要研究方向

1. 神经系统应激以及抑郁症等神经、精神类疾病的发病机制

2. 神经突触可塑性,及其在抑郁症发病中的作用及机制

3. 抗抑郁药物作用的细胞与分子机制


近年主持的课题

1. 小胶质细胞外泌体miR-146a-5p通过KLF4/CDK5途径调控抑郁症大鼠海马神经发生 No820715132021.1-2024.12: 国家自然基金 面上基金)

2. 小胶质细胞源性IL-1β通过SSH1/Cofilin调控突触可塑性介导抑郁症发病的机制研究 No818737962018.1-2022.12: 国家自然基金  面上基金)

3. miRNA-134介导的突触可塑性调节在抑郁症发病中的作用及机制研究 No814713712015.1-2018.12: 国家自然基金  面上基金)

4.谷氨酸受体介导的突触可塑性在抑郁症发病中的作用与机制。(No811010062012.1-2014.12 国家自然基金  青年基金)

5. IL-1β介导的神经可塑性调节在抑郁症发病与治疗中的机制研究 No2018GSF1180502018.1 2019.12: 山东省重点研发计划)

6. 类脑计算关键技术及其多模态信息处理应用 (No2017CXGC15042017.1-2019.12: 山东省重大科技创新工程项目(子课题))

7. MiRNA224-3P介导自噬相关蛋白调控胶质瘤干细胞干性对放化疗敏感性的研究 No2018JC0082018.01-2020.12:山东大学基本科研业务费交叉学科培育项目)

8. 应用微丝电极阵列模块研究抑郁症的发病机制及其药物治疗(No2015GGH3180242015.1-2016.12: 山东省重点研发计划)

9SIRT1调控抑郁症大鼠杏仁核突触可塑性的研究 No2014T70650 2014.10-2016.10 中国博士后科学基金特别资助)

10ERK信号途径诱导的AMPA受体迁移在焦虑症发病中的作用与机制。(NoBS2010SW0212010 - 2013 山东省优秀中青年科学家奖励基金

11ERK介导的神经结构可塑性在抑郁症发病中的作用及机制。(No: 2012M5213482012.10 - 2014.10  中国博士后面上科学基金

12.杏仁核神经元网络突触可塑性在抑郁症发病中的作用与机制研究。(No: 2012020462012-2014 济南市科学技术局高校院所创新基金)

13AMPA型谷氨酸受体迁移在焦虑症发病中的作用与机制。(No: 2010TS0912010-2012 山东大学自主创新基金)


代表性学术论文 *为通讯作者

1. Ye Li, Cuiqin Fan, Liyan Wang, Tian Lan, Rui Gao, Wenjing Wang, Shu Yan Yu. MicroRNA-26a-3p rescues depression-like behaviors in male rats via preventing hippocampal neuronal anomalies. The Journal of Clinical Investigation. 2021 August 16; 131(16): e148853. PubMed

2. Jie Shen, Ping Zhang, Ye Li, Cuiqin Fan, Tian Lan, Wenjing Wang, Shu Yan Yu. Neuroprotective effects of microRNA-211-5p on chronic stress-induced neuronal apoptosis and depression-like behaviors. Journal of Cellular and Molecular Medicine. 2021 Jul;25(14):7028-7038. PubMed

3. Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu. Hippocampal miR-211-5p regulates neurogenesis and depression-like behaviors in the rat. Neuropharmacology. 2021 Aug 15; 194:108618. PubMed

4. Cuiqin Fan, Yifei Long, Liyan Wang, Xiaohang Liu, Zhicheng Liu, Tian Lan, Ye Li, Shu Yan Yu. N-acetylcysteine rescues hippocampal oxidative stress-induced neuronal injury via suppression of p38/JNK signaling in depressed rats. Frontiers in Cellular Neuroscience. 2020 Nov 1, fncel.2020.554613.  PubMed

5. Ye Li, Liyan Wang, Peng Wang, Cuiqin Fan, Ping Zhang, Jie Shen, Shu Yan Yu*. Ginsenoside Rg1 rescues stress-induced depression-like behaviors via suppression of neural injury within the hippocampal CA1 region of rats. Oxidative Medicine and Cellular Longevity. 2020 Mar 18;2020:2325391. doi: 10.1155/2020/2325391. eCollection 2020.  PubMed

6. Song Q, Feng YB, Wang L, Shen J, Li Y, Fan C, Wang P, Shu Yan Yu*. COX-2 inhibition rescues depression-like behaviors via suppressing glial activation, oxidative stress and neuronal apoptosis in rats. Neuropharmacology. 2019, December 1, 160: 107779. PunMed

7. Wang P, Feng YB, Wang L, Li Y, Fan C, Song Q, Shu Yan Yu*. Interleukin-6: Its role and mechanisms in rescuing depression-like behaviors in rat models of depression. Brain Behav Immun. 2019 Nov; 82:106-121.  PubMed

8. Fan C, Song Q, Wang P, Li Y, Yang M, Shu Yan Yu*. Neuroprotective effects of curcumin on IL-1β-induced neuronal apoptosis and depression-like behaviors caused by chronic stress in rats. Frontiers in Cellular Neuroscience. 2019 Jan 07, 12:516.  PubMed

9. Fan C, Song Q, Wang P, Li Y, Yang M, Shu Yan Yu*. Neuroprotective effects of ginsenoside-Rg1 against depression-like behaviors via suppressing glial activation, synaptic deficits, and neuronal apoptosis in rats. Frontiers in Immunology. 2018 Dec 07, 9:2889. PubMed

10. Song Q, Fan C, Wang P, Li Y, Yang M, Shu Yan Yu*. Hippocampal CA1 βCaMKII mediates neuroinflammatory responses via COX-2/PGE2 signaling pathways in depression. Journal of Neuroinflammation. 2018 Dec 08;15:338  PubMed

11. Fan C, Song Q, Wang P, Li Y, Yang M, Liu B, Shu Yan Yu*. Curcumin Protects Against Chronic Stress-induced Dysregulation of Neuroplasticity and Depression-like Behaviors via Suppressing IL-1β Pathway in Rats. Neuroscience. 2018, 392: 92-106. PubMed

12. Fan C, Zhu X, Song Q, Wang P, Liu Z, Shu Yan Yu*. MiR-134 modulates chronic stress-induced structural plasticity and depression-like behaviors via downregulation of Limk1/cofilin signaling in rats. Neuropharmacology. 2018, 131: 364–376. PubMed

13. Zhu X, Gao R, Liu Z, Cheng Z, Qi Y, Fan C, Shu Yan Yu*. Ginsenoside Rg1 reverses stress-induced depression-like behaviors and BDNF expression within the prefrontal cortex. European Journal of Neuroscience. Volume44, July 2016, 1878-1885. PubMed

14. Liu Z, Qi Y, Cheng Z, Zhu X, Fan C, Shu Yan Yu*. The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats. Neuroscience. Volume 322, 13 May 2016, 358–369. PubMed

15. Zhang L, Luo JX, Zhang M, Yao W, Ma X, Shu Yan Yu*. Effects of curcumin on chronic unpredictable mild stress-induced depressive-like behavior and structural plasticity in the lateral amygdala of rats. The International Journal of Neuropsychopharmacology. 2014 May; 1705:793-806   PubMed

16. Luo JX, Zhang L, Ning NN, Jiang H, Shu Yan Yu*. Neotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat. Behavioural Brain Research. 2013, 253:48-53. PubMed

17. Lin Zhang, Tianyuan Xu, Shuang Wang, Lanqing Yu, Dexiang Liu, Renzhi Zhan, Shu Yan Yu*. NMDA GluN2B receptors involved in the antidepressant effects of curcumin in the forced swim test. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 40: 12–17. PubMed

18. Shu Yan Yu, Zhang M, Luo J, Zhang L, Shao Y, Li G*. Curcumin ameliorates memory deficits via neuronal nitric oxide synthase in aged mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 45:47-53.  PubMed

19. Shu Yan Yu*, Gao R, Zhang LLuo J, Jiang H, Wang S. Curcumin ameliorates ethanol-induced memory deficits and enhanced brain nitric oxide synthase activity in mice. Prog Neuropsychopharmacol Biol Psychiatry. 2013, 44:210-6.  PubMed

20. Lin Zhang, Tianyuan Xu, Shuang Wang, Lanqing Yu, Dexiang Liu, Renzhi Zhan, Shu Yan Yu*. Curcumin produces antidepressant effects via activating MAPK/ERK- dependent brain-derived neurotrophic factor expression in the amygdala of mice. Behavioural Brain Research. 2012, 235(1):67-72. PubMed

21. Lin Zhang, Hui Wang, Qin Li, Renzhi Zhan, Shu Yan Yu*. Purinergic modulation of hypoxic regulation via the rostral ventral lateral medulla in rats. Respiratory Physiology Neurobiology. 2012, 184(1): 48-54. PubMed

22. Shu Yan Yu*, Wang G, Wang H, Zhang H, Li Q. Raphe pallidus modulate Bötzinger complex induced inhibition of the phrenic nerve activity in rats. European Journal of Neuroscience. 2011, 34(7):1113-20. PubMed

23. Shu Yan Yu*, Wu DC, Zhan RZ. GluN2B subunits of the NMDA receptor contribute  to the AMPA receptor internalization during long-term depression in the lateral amygdala of juvenile rats. Neuroscience. 2010, 171(4):1102-8.  PubMed

24. Shu Yan Yu, Wu DC, Liu L, Ge Y, Wang YT *. Role of AMPA receptor trafficking in NMDA receptor-dependent synaptic plasticity in the rat lateral amygdala. Journal of Neurochemistry. 2008, 106(2):889-99. PubMed


 
上一条:姚伟

关闭


 
版权所有:山东大学基础医学院生理与病理生理学系  地址:山东省济南市文化西路44号山东大学基础医学院生理与病理生理学系  邮编:250012  电话:0531-88382044